Publications & Patents

(33) Takahashi-Ruiz, L., Morris, J.D., Crews, P., Johnson, T.A., and Risinger, A.L.. In Vivo Evaluation of (-)-Zampanolide Demonstrates Potent and Persistent Antitumor Efficacy When Targeted to the Tumor Site.

Molecules, 2022,  [PDF] [SI] 

(32) Morris, J. D., Takahashi-Ruiz, L., Persi, L. N., Summers, J. C., McCauley, E. P., Chan, P. Y. W., Amberchan, G., Lizama-Chamu, I., Coppage, D. A., Crews, P., Risinger, A. L., Johnson, T. A.. Re-evaluation of the Fijianolide/Laulimalide Chemotype Suggests an Alternate Mechanism of Action for C-15/C-20 Analogs.

ACS Omega, 2022,  [PDF] [SI]

(31) Coming soon...

Johnson, T.A., Cook, C.V., McIntosh, N.L., Morris, J.D., Valeriote, F.A., Henderson, J.S., Crews, P., Media, J., & Maheshwari, M. 

Novel Compounds Related to Mycothiazole and Methods of Treating Cancer.  

United States Patent and Trademark Office (USPTO application no. 17/149,203)

January 14, 2021.

(30) Johnson, T. A., Morris, J. D., Coppage, D. A., Cook, C. V., Persi, L. N., Ogarrio, M. A., Garcia, T. C., McIntosh, N. L., McCauley, E. P., Media, J., Maheshwari, M., Valeriote, F. A., Shaw, J., Crews, P.. Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8S Configuration.

ACS Medicinal Chemistry Letters, 2020, 11(2), 108–113. [PDF] [SI]

(29) McAlpine J.B., Chen S.N., Kutateladze A., MacMillan J.B., Appendino G., Barison A., Beniddir M.A., Biavatti M.W., Bluml S., Boufridi A., Butler M.S., Capon R.J., Choi Y.H., Coppage D., Crews P., Crimmins M.T., Csete M., Dewapriya P., Egan J.M., Garson M.J., Genta-Jouve G., Gerwick W.H., Gross H., Harper M.K., Hermanto P., Hook J.M., Hunter L., Jeannerat D., Ji N.Y., Johnson T.A., Kingston D.G.I., Koshino H., Lee H.W., Lewin G., Li J., Linington R.G., Liu M., McPhail K.L., Molinski T.F., Moore B.S., Nam J.W., Neupane R.P., Niemitz M., Nuzillard J.M., Oberlies N.H., Ocampos F.M.M., Pan G., Quinn R.J., Reddy D.S., Renault J.H., Rivera-Chávez J., Robien W., Saunders C.M., Schmidt T.J., Seger C., Shen B., Steinbeck C., Stuppner H., Sturm S., Taglialatela-Scafati O., Tantillo D.J., Verpoorte R., Wang B.G., Williams C.M., Williams P.G., Wist J., Yue J.M., Zhang C., Xu Z., Simmler C., Lankin D.C., Bisson J., Pauli G.F.. The Value of Universally Available Raw NMR Data for Transparency, Reproducibility, and Integrity in Natural Product Research.

Natural Product Reports, 2019, 36(1), 35–37.  [PDF]

(28) Lorig-Roach, N., Hamkins-Indik, F., Johnson, T. A., Tenney, K., Valeriote, F. A., Crews, P. The Potential of Achiral Sponge-Derived and Synthetic Bromoindoles as Selective Cytotoxins Against PANC-1 Tumor Cells.

Tetrahedron, 2018, 74(2), 217–223. [PDF] [SI]

(27) Lin, S., McCauley, E. P., Lorig-Roach, N., Tenney, K., Naphen, C. N., Yang, A. M., Johnson, T. A., Hernadez, T., Rattan, R., Valeriote, F. A., Crews, P.. Another Look at Pyrroloiminoquinone Alkaloids-Perspectives on Their Therapeutic Potential from Known Structures and Semisynthetic Analogues.

Marine Drugs, 2017, 15(4), 98. [PDF] [SI]

(26) Johnson, T. A., Milan-Lobo, L., Che, T., Ferwerda, M., Lambu, E., McIntosh, N. L., Li, F., He, L., Lorig-Roach, N., Crews, P., Whistler, J. L. . Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the Endorphins.

ACS Chemical Neuroscience, 2017, 8(3), 473–485. [PDF] [SI]

(25) Theodore, C. M., Lorig-Roach, N., Still, P. C., Johnson, T. A., Drašković, M., Schwochert, J. A., Naphen, C. N., Crews, M. S., Barker, S. A., Valeriote, F. A., Lokey, R. S., Crews, P.. Biosynthetic Products from a Nearshore-Derived Gram-Negative Bacterium Enable Reassessment of the Kailuin Depsipeptides.

Journal of Natural Products, 2015, 78(3), 441–452. [PDF]

(24) Still, P. C., Johnson, T. A., Theodore, C. M., Loveridge, S. T., Crews, P.. Scrutinizing the Scaffolds of Marine Biosynthetics from Different Source Organisms: Gram-Negative Cultured Bacterial Products Enter Center Stage.

Journal of Natural Products, 2014, 77(3), 690–702. [PDF]

(23) Johnson, T. A., Sohn, J., Ward, A. E., Cohen, T. L., Lorig-Roach, N. D., Chen, H., Pilli, R. A., Widjaja, E. A., Hanafi, M., Kardono, L. B., Lotulung, P. D., Boundy-Mills, K., Bjeldanes, L. F. (+)-Altholactone Exhibits Broad Spectrum Immune Modulating Activity by Inhibiting the Activation of Pro-Inflammatory Cytokines in RAW 264.7 Cell Lines.

Bioorganic & Medicinal Chemistry, 2013, 21(14), 4358–4364. [PDF]

(22) Rohena, C. C., Peng, J., Johnson, T. A., Crews, P., Mooberry, S. L. Chemically Diverse Microtubule Stabilizing Agents Initiate Distinct Mitotic Defects and Dysregulated Expression of Key Mitotic Kinases.

Biochemical Pharmacology, 2013, 85(8), 1104–1114. [PDF]

(21) Johnson, T. A., Sohn, J., Inman, W. D., Bjeldanes, L. F., Rayburn, K.. Lipophilic Stinging Nettle Extracts Possess Potent Anti-Inflammatory Activity, Are Not Cytotoxic, and May be Superior to Traditional Tinctures for Treating Inflammatory Disorders.

Phytomedicine, 2013, 20(2), 143–147. [PDF]

(20) Johnson, T. A., Sohn, J., Vaske, Y. M., White, K. N., Cohen, T. L., Vervoort, H. C., Tenney, K., Valeriote, F. A., Bjeldanes, L. F., Crews, P.  Myxobacteria Versus Sponge-Derived Alkaloids: the Bengamide Family Identified as Potent Immune Modulating Agents by Scrutiny of LC-MS/ELSD Libraries.

Bioorganic & Medicinal Chemistry, 2012, 20(14), 4348–4355. [PDF] [SI]

(19) Valeriote, F. A., Tenney, K., Media, J., Pietraszkiewicz, H., Edelstein, M., Johnson, T. A., Amagata, T., Crews, P.  Discovery and Development of Anticancer Agents from Marine Sponges: Perspectives Based on a Chemistry-Experimental Therapeutics Collaborative Program.

Journal of Experimental Therapeutics & Oncology, 2012, 10(2), 119–134. 

(18) Johnson, T. A., Sohn, J., Inman, W. D., Estee, S. A., Loveridge, S. T., Vervoort, H. C., Tenney, K., Liu, J., Ang, K. K., Ratnam, J., Bray, W. M., Gassner, N. C., Shen, Y. Y., Lokey, R. S., McKerrow, J. H., Boundy-Mills, K., Nukanto, A., Kanti, A., Julistiono, H., Kardono, L. B., Bjeldanes L. F., Crews, P.. Natural Product Libraries to Accelerate the High-Throughput Discovery of Therapeutic Leads.

Journal of Natural Products, 2011, 74(12), 2545–2555. [PDF] [SI]

(17) Crews, P.; Amagata, T.; Johnson, T. A.; Tenney, K.; Mooberry, S. L.; Valeriote, F. A.

Latrunculol Derivatives From Sea Sponges.   PATENT PCT Int. Appl. 2010, 32 pp. WO 2010014240   A2 20100204

(16) Wu, Q. X., Crews, M. S., Draskovic, M., Sohn, J., Johnson, T. A., Tenney, K., Valeriote, F. A., Yao, X. J., Bjeldanes, L. F., Crews, P.

Azonazine, a Novel Dipeptide from a Hawaiian Marine Sediment-Derived Fungus, Aspergillus insulicola.

Organic Letters, 2010, 12(20), 4458–4461. [PDF] [SI]

(15) Morgan, J. B., Mahdi, F., Liu, Y., Coothankandaswamy, V., Jekabsons, M. B., Johnson, T. A., Sashidhara, K. V., Crews, P., Nagle, D. G.,  Zhou, Y. D. The Marine Sponge Metabolite Mycothiazole: a Novel Prototype Mitochondrial Complex I Inhibitor.

Bioorganic & Medicinal Chemistry, 2010 18(16), 5988–5994. [PDF] [SI]

(14) Johnson, T. A., Morgan, M. V., Aratow, N. A., Estee, S. A., Sashidhara, K. V., Loveridge, S. T., Segraves, N. L., Crews, P.

Assessing Pressurized Liquid Extraction for the High-Throughput Extraction of Marine-Sponge-Derived Natural Products.

Journal of Natural Products, 2010, 73(3), 359–364. [PDF] [SI]

(13) Shaw, J., Valeriote, F. A., Media, J., Johnson, T. A., Amagata, T., Tenney, K., Crews, P.

Development and Validation of a Rapid Method for the Detection of Latrunculol A in Plasma.

Analytical and Bioanalytical Chemistry, 2010, 396 (5), 1741–1744. [PDF]

(12) Johnson, T. A., Amagata, T., Sashidhara, K. V., Oliver, A. G., Tenney, K., Matainaho, T., Ang, K. K., McKerrow, J. H., Crews, P.

The Aignopsanes, a New Class of Sesquiterpenes from Selected Chemotypes of the Sponge Cacospongia mycofijiensis.

Organic Letters, 2009, 11(9), 1975–1978. [PDF] [SI]

(11) Jessup, D. A., Miller, M. A., Ryan, J. P., Nevins, H. M., Kerkering, H. A., Mekebri, A., Crane, D. B., Johnson, T. A., Kudela, R. M..

Mass Stranding of Marine Birds Caused by a Surfactant-Producing Red Tide.

PloS One, 4(2), 2009, e4550. [PDF]

(10) Amagata, T., Johnson, T. A., Cichewicz, R. H., Tenney, K., Mooberry, S. L., Media, J., Edelstein, M., Valeriote, F. A., Crews, P. Interrogating the Bioactive Pharmacophore of the Latrunculin Chemotype by Investigating the Metabolites of Two Taxonomically Unrelated Sponges.

Journal of Medicinal Chemistry, 2008, 51(22), 7234–7242. [PDF] [SI]

(9) Johnson, T. A., Amagata, T., Oliver, A. G., Tenney, K., Valeriote, F. A., Crews, P.  The Unexpected Isolation of CTP-431, a Novel Thiopyrone from the Sponge Cacospongia mycofijiensis.

Journal of Organic Chemistry, 2008, 73(18), 7255–7259. [PDF] [SI]

(8) Litaker, R. W., LeEberhardt, B., Wekell, J. C., Trainer, V. L., Kudela, R. M., Roberts, A., Hertz, C., Johnson, T. A., Frankfurter, G.;,Smith, J. G., Schnetzer, A., Hardison, R.;,Tester, P.

Rapid Enzyme-liked Immunosorbent Assay for Detection of the Algal Toxin Domoic Acid.

Journal of Shellfish Research, 2008, 27, 1301-1310.     [PDF]

(7) Deschamps, J. D., Gautschi, J. T., Whitman, S., Johnson, T. A., Gassner, N. C., Crews, P., Holman, T. R.. Discovery of Platelet-type 12-Human Lipoxygenase Selective Inhibitors by High-Throughput Screening of Structurally Diverse Libraries.

Bioorganic & Medicinal Chemistry, 2007, 15(22), 6900–6908. [PDF] 

(6) Johnson, T. A., Tenney, K., Cichewicz, R. H., Morinaka, B. I., White, K. N., Amagata, T., Subramanian, B., Media, J., Mooberry, S. L., Valeriote, F. A., Crews, P. Sponge-Derived Fijianolide Polyketide Class: Further Evaluation of Their Structural and Cytotoxicity Properties.

Journal of Medicinal Chemistry, 2007, 50(16), 3795–3803. [PDF] [SI]

(5) Sonnenschein, R. N., Johnson, T. A., Tenney, K., Valeriote, F. A., Crews, P. A.

Reassignment of (-)-Mycothiazole and the Isolation of a Related Diol.

Journal of Natural Products, 2006, 69(1), 145–147. [PDF] [SI]

(4) Segraves, E. N., Shah, R. R., Segraves, N. L., Johnson, T. A., Whitman, S., Sui, J. K., Kenyon, V. A., Cichewicz, R. H., Crews, P., Holman, T. R. Probing the Activity Differences of Simple and Complex Brominated Aryl Compounds Against 15-Soybean, 15-Human, and 12-Human Lipoxygenase.

Journal of Medicinal Chemistry, 2004, 47(16), 4060–4065. [PDF] [SI]

(3) Amagata, T., Whitman, S., Johnson, T. A., Stessman, C. C., Loo, C. P., Lobkovsky, E., Clardy, J., Crews, P., Holman, T. R. Exploring Sponge-Derived Terpenoids for Their Potency and Selectivity Against 12-Human, 15-Human, and 15-Soybean Lipoxygenases.

Journal of Natural Products, 2003, 66(2), 230–235. [PDF] [SI]

(2) Segraves, N. L., Lopez, S., Johnson, T. A., Said, S. A., Xiong F., Schmitz, F. J., Halina, P., Valeriote, F. A., Crews, P.. Structures and Cytotoxicities of Fascaplysin and Related Alkaloids from Two Marine Phyla - Fascaplysinopsis sponges and Didemnum tunicates.

Tetrahedron Letters, 2003, 44, 3471-3475. [PDF]

(1) Thale, Z., Johnson, T. A., Tenney, K., Wenzel, P. J., Lobkvovsky, E.; Clardy, J., Media, J., Pietraszkiewicz, H., Valeriote, F. A., Crews, P.

Structures and Cytotoxic Properties of Sponge-Derived Bisannulated Acridines.

Journal of Organic Chemistry, 2002, 67, 9384-9391. [PDF] [SI]